NAD+ 1000mg

82.00

NAD⁺ (oxidized nicotinamide adenine dinucleotide) is a ubiquitous pyridine nucleotide coenzyme that accepts hydride ions in key metabolic pathways—glycolysis, the tricarboxylic acid cycle, and fatty-acid β-oxidation—to generate NADH for ATP production via oxidative phosphorylation. Beyond its redox role, NAD⁺ serves as an essential cosubstrate for NAD⁺-consuming enzymes such as sirtuin deacetylases and poly-ADP-ribose polymerases, thereby regulating gene expression, DNA-damage repair, and cellular stress responses. NAD⁺ availability also modulates mitochondrial biogenesis and metabolic homeostasis through SIRT1-PGC-1α signaling and impacts aging-related processes, as cellular NAD⁺ levels decline with age.

 
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          Description
          NAD⁺ (oxidized nicotinamide adenine dinucleotide) is a ubiquitous pyridine nucleotide coenzyme that accepts hydride ions in key metabolic pathways—glycolysis, the tricarboxylic acid cycle, and fatty-acid β-oxidation—to generate NADH for ATP production via oxidative phosphorylation. Beyond its redox role, NAD⁺ serves as an essential cosubstrate for NAD⁺-consuming enzymes such as sirtuin deacetylases and poly-ADP-ribose polymerases, thereby regulating gene expression, DNA-damage repair, and cellular stress responses. NAD⁺ availability also modulates mitochondrial biogenesis and metabolic homeostasis through SIRT1-PGC-1α signaling and impacts aging-related processes, as cellular NAD⁺ levels decline with age.
           

          Product details

          Chemical Name:

          Nicotinamide Adenine Dinucleotide (oxidized form)

          Molecular Formula:

          C₂₁H₂₇N₇O₁₄P₂

          Molecular Weight:

          663.43 g/mol

          PubChem CID:

          5883

          CAS Number:

          53-84-9
          Synonyms:
          NAD⁺, Coenzyme I

          Vial Size:

          10 mL

          Contents:

          Lyophilized powder, white/off-white color
           

          Mechanism of action

          Redox Coenzyme in Bioenergetics

          NAD⁺ accepts hydride ions from key metabolic pathways—glycolysis, the tricarboxylic acid (TCA) cycle, and fatty‐acid β-oxidation—to form NADH, which then donates electrons to the mitochondrial electron‐transport chain for ATP synthesis via oxidative phosphorylation

          Substrate for NAD⁺-Consuming Enzymes

          Serves as an obligatory co-substrate for sirtuin deacetylases (e.g., SIRT1/3), poly-ADP-ribose polymerases (PARPs), and the NADase CD38, thereby regulating protein deacetylation, DNA-damage–response ADP-ribosylation, and calcium signaling.

          Modulation of Gene Expression & Stress Responses

          Through SIRT1-mediated deacetylation of transcriptional regulators (e.g., PGC-1α) and PARP-driven DNA repair, NAD⁺ levels fine-tune mitochondrial biogenesis, antioxidant defenses, and genomic stability under stress conditions.

          Salvage Pathway & Mitochondrial Health

          The NAMPT-dependent salvage pathway recycles nicotinamide into NAD⁺, sustaining intracellular pools; conversely, age-associated CD38 upregulation degrades NAD⁺, contributing to mitochondrial dysfunction.
           

          Storage & handling

          Storage

          Store the lyophilized vial in a cool, dry area protected from direct sunlight.